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HealthspanX / Publication archive
Explore individual publications and their study records. Read the source, the findings and the limits together.
Preclinical mechanistic study / 2018
Isotope-tracer study quantified NAD flux and found route-dependent NMN/NR metabolism in mice, with extensive conversion after oral administration.
Cell Metabolism
Read study recordCellular and structural study / 2016
Mechanistic cell/mouse study found NRK1 is central to NMN/NR utilization and supported extracellular NMN-to-NR conversion in studied systems.
Nature Communications
Read study recordPreclinical mechanistic study / 2016
Landmark 12-month mouse study found NMN altered multiple age-associated physiological and metabolic measures without obvious toxicity in the model.
Cell Metabolism
Read study recordPreclinical mechanistic study / 2016
Aged-mouse study found NMN improved endothelial function, arterial stiffness and oxidative-stress measures; translation to human vascular outcomes is unproven.
Aging Cell
Read study recordPreclinical mechanistic study / 2014
Mouse cardiac study found NMN increased NAD+ and reduced ischemia/reperfusion injury under experimental conditions; no human cardiovascular efficacy was tested.
PLOS ONE
Read study recordPreclinical mechanistic study / 2011
Foundational mouse study: NMN restored NAD+ and improved glucose-related metabolic phenotypes in diet- and age-associated diabetes models.
Cell Metabolism
Read study recordSystematic review and meta-analysis / 2026
2026 meta-analysis of 15 RCTs found favorable short-term tolerability but no clear pooled benefit for most metabolic outcomes; long-term safety remains unknown.
Nutrients
Read study recordSystematic review and meta-analysis / 2026
Meta-analysis of 10 RCTs (349 participants) found no significant overall systolic reduction and a small preliminary diastolic-pressure signal.
Nutrients
Read study recordSystematic review and meta-analysis / 2025
Systematic review/meta-analysis found no consistent evidence that NMN improves core skeletal-muscle mass or function outcomes; NMN-specific data were limited.
Journal of Cachexia, Sarcopenia and Muscle
Read study recordSystematic review and meta-analysis / 2025
Meta-analysis of 9 NMN trials in middle-aged/older adults found a limited, heterogeneous evidence base for muscle, liver and metabolic outcomes.
Current Pharmaceutical Biotechnology
Read study recordSystematic review / 2024
Systematic review of 10 RCTs (437 participants) found physical-performance changes were non-significant overall and reported no serious adverse effects.
Cureus
Read study recordSystematic review and meta-analysis / 2025
Systematic review of 12 studies (513 adults) found robust NAD biomarker increases but inconsistent evidence for conventional glucose and lipid benefits.
Critical Reviews in Food Science and Nutrition
Read study recordThe Evidence Center brings study design, findings and limitations into the same view.
