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HealthspanX / Publication archive
Explore individual publications and their study records. Read the source, the findings and the limits together.
Cellular and structural study / 2021
Mouse brain endothelial-cell study found NMN attenuated hydrogen-peroxide-induced oxidative stress, apoptosis, and NF-κB inflammatory signaling while increasing NAMPT-related endothelial markers.
FEBS Open Bio
Read study recordPreclinical mechanistic study / 2023
Mouse spinal-cord-injury study reported restored NAD+, improved motor recovery, reduced pain-related behavior, and broad suppression of inflammatory transcriptional pathways with NMN.
Frontiers in Cellular Neuroscience
Read study recordPreclinical mechanistic study / 2025
Mouse PCOS-oocyte study found NMN improved in-vitro maturation, NAD+, mitochondrial function, oxidative-stress measures, and spindle integrity through an NMNAT/SIRT1-linked mechanism.
The FASEB Journal
Read study recordPreclinical mechanistic study / 2025
Rat and cell study found NMN attenuated hyperoxia-aggravated septic lung injury through SIRT6/GPx4-linked suppression of ferroptosis.
Free Radical Biology and Medicine
Read study recordPreclinical mechanistic study / 2026
Mouse mesothelioma and human immune-cell study found high-dose NMN shifted tumor-associated macrophages toward an inflammatory M1-like phenotype and reduced tumor growth in the model.
Molecular Therapy Oncology
Read study recordPreclinical mechanistic study / 2025
Mouse chemotherapy study reported that NMN preserved ovarian, oocyte, and embryo-development measures during cyclophosphamide exposure.
Journal of Ovarian Research
Read study recordCellular and structural study / 2022
Human iPSC-neuron study found NMN pretreatment attenuated cisplatin-induced mitochondrial oxidative, energetic, and structural defects in vitro.
Brain Plasticity
Read study recordPreclinical mechanistic study / 2023
Mouse sepsis study reported NMN-associated improvements in organ injury, bacterial clearance, inflammation, and survival, with SIRT3-linked mechanisms.
Journal of Translational Medicine
Read study recordPreclinical mechanistic study / 2025
Mechanistic study identified CD38-mediated base exchange of NMN with nicotinic acid to form NaMN and validated the pathway in mice.
Journal of Biological Chemistry
Read study recordPreclinical mechanistic study / 2025
ApoE-knockout mouse study found NMN/NR improved lipids and fatty liver but worsened atherosclerosis at higher experimental doses.
Pharmaceuticals (Basel)
Read study recordPreclinical mechanistic study / 2025
Mouse tracer study found oral NMN and NR raise NAD+ largely through microbiome-linked deamidation and enterohepatic recycling, with limited direct precursor contribution.
Science Advances
Read study recordPreclinical mechanistic study / 2026
HFD aging-mouse study found NMN reduced cardiac injury markers and activated Sirt3/PINK1/Parkin-related autophagy; no human cardiomyopathy efficacy was tested.
The Journal of Nutrition
Read study recordThe Evidence Center brings study design, findings and limitations into the same view.
