This study examined vascular aging in mice and tested whether NMN could restore vascular function in old animals.
In aged mice, NMN improved endothelium-dependent dilation, reduced arterial stiffness and oxidative-stress measures, and altered vascular SIRT1, collagen and elastin-related markers toward values seen in younger mice.
These are substantial preclinical vascular findings, but they do not establish that NMN lowers cardiovascular risk or reverses arterial aging in people.
Key findings
NMN restored endothelium-dependent dilation in aged mice.
Aortic pulse-wave velocity and elastic modulus were reduced in treated old mice.
Oxidative-stress markers decreased and vascular SIRT1-related activity was restored.
Acute NMN exposure increased NAD+ in isolated aortic tissue.
What it cannot establish
Mouse study only.
Vascular surrogate and molecular endpoints are not human cardiovascular events.
Animal dosing and tissue exposure may not reflect oral human supplementation.
Human trials are needed before clinical vascular claims can be made.
HealthspanX claim boundary: This study does not establish that NMN reverses arterial aging, lowers cardiovascular risk, or treats vascular disease in humans.
