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HealthspanX / Publication archive
Explore individual publications and their study records. Read the source, the findings and the limits together.
Preclinical mechanistic study / 2026
2026 aged-mouse study found NMN improved follicle-reserve and mitochondrial measures, with 500 mg/kg/day best among tested doses; no human efficacy was tested.
Reproductive Sciences
Read study recordPreclinical mechanistic study / 2025
Aging-mouse study found NMN slowed hearing-loss progression and raised inner-ear NAD+; all authors were company-affiliated and no human hearing outcomes were tested.
Hearing Research
Read study recordPreclinical mechanistic study / 2025
Seven-month HFD aging-mouse study found NMN altered metabolic, physical, renal, inflammatory and autophagy measures; human effects are unproven.
The Journal of Nutrition
Read study recordPreclinical mechanistic study / 2024
Aged-mouse study found NMN increased ovarian NAD+ and altered ovarian, mitochondrial, metabolic and inflammatory measures; no human efficacy was tested.
MedComm
Read study recordPreclinical mechanistic study / 2022
Long-term aged-mouse study found NMN altered ovarian reserve, follicle counts and granulosa-cell mitophagy; human fertility relevance is unproven.
The Journal of Nutritional Biochemistry
Read study recordPreclinical mechanistic study / 2021
Mouse study found long-term NMN altered gut microbiota, bile-acid metabolites and intestinal-barrier measures; human gut effects are unknown.
Frontiers in Nutrition
Read study recordPreclinical mechanistic study / 2020
Aged-mouse study found NMN improved oocyte NAD+, meiotic and fertilization-related measures and mitochondrial function; human effects are unknown.
Cell Reports
Read study recordPreclinical mechanistic study / 2020
Reproductive-aging mouse study found NAD+ repletion including NMN improved oocyte and fertility-related outcomes; no human fertility efficacy was tested.
Cell Reports
Read study recordPreclinical mechanistic study / 2020
Aged-mouse RNA-seq study found 204 age-associated neurovascular genes shifted toward younger expression after NMN; findings are mechanistic, not clinical.
GeroScience
Read study recordPreclinical mechanistic study / 2019
Aged-mouse study found NMN improved neurovascular coupling, endothelial function and selected cognitive/gait measures; human relevance remains unproven.
Redox Biology
Read study recordCellular and structural study / 2019
Nature Metabolism critique argued evidence was insufficient to establish SLC12A8 as an NMN transporter, directly contesting Grozio et al. 2019.
Nature Metabolism
Read study recordCellular and structural study / 2019
Cell/mouse study proposed SLC12A8 as a specific NMN transporter; a later published critique disputed that conclusion.
Nature Metabolism
Read study recordThe Evidence Center brings study design, findings and limitations into the same view.
