Preclinical animal study

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

Yilong Miao et al. · Cell Reports · 2020

Evidence type: Preclinical mechanistic study Interpretive weight: Mechanistic contextResearch area: Oocyte and reproductive aging
DesignPreclinical study of naturally aged female mice, oocytes and single-cell transcriptomics
PopulationNaturally aged female mice and isolated oocytes
SampleMultiple mouse and oocyte cohorts; see publication
InterventionIn-vivo NMN supplementation in aged mice
EndpointsOocyte NAD+; Ovulation; Meiotic competence; Fertilization ability; Spindle and chromosome structure; Mitochondrial function; Reactive oxygen species and apoptosis; Single-cell transcriptome

What the publication reported

This independent mouse study examined whether NMN could alter age-related deterioration in oocyte quality.

NMN restored oocyte NAD+ and was associated with improved ovulation, meiotic competence, fertilization-related measures, spindle and chromosome structure, and mitochondrial function in aged mice.

Although the results complement other reproductive-aging work, they remain animal data and do not establish fertility effects in women.

Key findings

  • NMN increased NAD+ in oocytes from aged mice.
  • Ovulation, meiotic competence and fertilization-related measures improved in the model.
  • Spindle/chromosome and cortical-granule-related abnormalities were reduced.
  • Mitochondrial function improved and oxidative-stress/apoptosis measures declined.

What it cannot establish

  • Mouse and oocyte study only.
  • No human fertility or pregnancy outcomes.
  • Experimental dosing and reproductive timing may not translate to human supplementation.
  • Single-cell and cellular outcomes are mechanistic rather than clinical.
HealthspanX claim boundary: This study does not establish that NMN improves female fertility, egg quality, ovarian reserve, IVF outcomes or pregnancy in humans.

Continue reviewing

Return to the complete evidence library.

Evidence Center Ultra Pure NMN

Source fields verified