What human studies have reported
Research relevant to physical function, sleep, metabolism, and cellular NAD⁺.
NMN and the NAD⁺ pathway. NAD⁺ participates in cellular energy transfer, redox reactions, metabolic signaling, DNA-repair activity, and other cellular processes. NMN is a naturally occurring precursor the body can use in NAD⁺ biosynthesis. This defined relationship is one reason NMN has been examined in controlled human research.
Ingredientβ-nicotinamide mononucleotide
PathwayDirect precursor in NAD⁺ biosynthesis
Human findingRepeated increases in circulating NAD⁺-related measures
The findings below are drawn from the broader human NMN literature. Each finding reflects a defined population, dose, duration, and study material. Full study records are maintained in the HealthspanX Evidence Center.
EXERCISE PHYSIOLOGYNicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
Six-week, four-arm RCT (placebo / 300 / 600 / 1200 mg/day) in 48 amateur runners on ventilatory-threshold and aerobic-capacity measures.
Liao B et al. · Journal of the International Society of Sports Nutrition · 2021
Analysis in review These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.