NMN and Weight Loss: A Solution for Obesity?

NMN and Weight Loss in Overweight Adults

In a study published in The Journal of Clinical Endocrinology and Metabolism in 2023, Harvard Medical School researchers have shown that NMN supplementation can assist overweight adults in shedding weight. 

In the study, participants aged 45 and older, who were overweight, took a daily total of 2,000 mg of NMN for a month. The results were noteworthy. After taking NMN, participants experienced weight loss of over 6 lbs in just 28 days. 

Additionally, NMN proved effective in lowering both overall and "bad" LDL cholesterol levels. 

However, the study's duration was brief and involved a limited number of participants. It underscores the need for longer studies with a more extensive participant base. That way, we can validate NMN's full range of potential benefits. [1] 

NMN's Impact on Obesity-Related Metabolic Issues

When we consume sugary foods or drinks, our intestines release hormones called incretins to help manage the sugar. One of these hormones, GLP-1, plays a crucial role in controlling blood sugar levels. If this process gets disrupted, obesity can result. 

In a study published in Cells in 2020, researchers from Japan and St. Louis have found that NAD+ is vital for the intestines to produce GLP-1. In obese mice, the amount of NAD+ was low. That affected GLP-1 production and led to high sugar levels in the blood. The same results were seen in mice where a specific enzyme related to NAD+ production was removed.

Interestingly, when these mice were given water mixed with NMN (a precursor to NAD+), their NAD+ levels in the intestines got restored. This brought back the proper production of GLP-1 and regulated their sugar levels. 

The researchers conclude that understanding and managing intestinal NAD+ levels, especially using NMN, can be a way to address obesity-related sugar metabolism problems. NMN might also have a direct role in insulin secretion, which further helps in controlling blood sugar levels. Besides, NMN can be effective in weight loss strategies. 

While some studies showed that another NAD+-related molecule, nicotinamide riboside (NR), didn't have the same effect as NMN, researchers believe the reason could be the presence of a specific NMN transporter in the intestines.

Given the promising results, a clinical trial is underway in St. Louis to study the effect of NMN on human metabolic and cardiovascular health, expected to conclude by fall 2025. This could be a significant step in understanding NMN's potential benefits for weight loss, obesity-related metabolic problems, and human health in general . [2] 

NMN and Weight Loss: Insights from Studies on Male Mice Born to Obese Mothers

When mothers are obese, their offspring, whether male or female, are at a higher risk of obesity and related metabolic diseases. This fact has led researchers to seek treatments that can counteract these effects. 

A recent study conducted by Uddin and his team from The University of New South Wales in Sydney, published in Cells in 2020, delved into the benefits of NMN for male offspring born to obese mouse mothers. NMN has been previously shown to improve metabolism in female offspring. The researchers wanted to determine if similar benefits existed for male offspring.

The study found that male mice born to obese mothers and fed high-fat diets were significantly heavier than their counterparts. However, a short-term administration of NMN for just three weeks was able to reduce their fat levels and improve glucose tolerance, especially in those that were most affected by the combined impact of maternal obesity and a high-fat diet.

In essence, NMN seems to counteract some of the negative metabolic effects in male mice born to obese mothers, especially when they are exposed to unhealthy diets. This discovery suggests NMN could potentially be a beneficial treatment for metabolic issues arising from maternal obesity. NMN can also be a valuable weight loss supplement based on these results. [3]  

Conclusion

In the battle against global obesity, the role of NMN in weight loss emerges as a key aspect. In this context, NMN has emerged as a beacon of hope, potentially unlocking new avenues for managing weight and mitigating obesity-related health risks. The studies we've discussed illuminate the diverse and promising roles of NMN, from aiding in weight loss in overweight adults to addressing metabolic imbalances caused by obesity. The ongoing research and upcoming clinical trials are eagerly anticipated, as they promise to further clarify and expand our understanding of NMN's benefits.

Amidst these advancements, the introduction of products like HealthspanX's Ultra Pure NMN™ plays a crucial role. Such high-quality NMN, backed by rigorous scientific research and embraced under the guidance of healthcare professionals, could significantly contribute to our health in general and, of course, weight loss strategies. 

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