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How NMN Can Help You Feel Years Younger?

No Drastic Diets, No Workouts
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Break Free from Fatigue and Brain Fog. Restore Your Youthful Energy, Mental Clarity, and Vitality with HealthspanX Ultra Pure NMN™ for Less Than the Price of Your Morning Coffee!
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Every Day You Wait, Time Wins. Don't Wait!
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You wake up tired. You drag through the day, overwhelmed and sluggish. The mirror reflects more than wrinkles—it shows a fading spark.

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Supplements, energy drinks, miracle cures—they all promised results but left you disappointed. Now they sit untouched, reminding you of wasted money and broken promises.

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Ultra Pure NMN™ is your proven path to lasting energy, sharp focus, and youthful vitality.

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Fight Back and Feel Alive Again!

Exhausted? Foggy? Drained?

You wake up tired. You drag through the day, overwhelmed and sluggish. The mirror reflects more than wrinkles—it shows a fading spark.

You’ve Tried Everything, and Nothing Works?

Supplements, energy drinks, miracle cures—they all promised results but left you disappointed. Now they sit untouched, reminding you of wasted money and broken promises.

Every Day, You’re Slipping Further?

Your energy is gone. Your mind feels dull. You’re struggling to keep up with life, and the vibrant, confident you feels out of reach.

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Ultra Pure NMN™ is your proven path to lasting energy, sharp focus, and youthful vitality.

The #1 Solution for Energy, Focus, and Anti-Aging

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Ultra Pure NMN™ 500mg Capsules
Ultra Pure NMN™ 500mg Capsules
Ultra Pure NMN™ 500mg Capsules
Ultra Pure NMN™ 500mg Capsules
Ultra Pure NMN™ 500mg Capsules
Ultra Pure NMN™ 500mg Capsules
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Frequently Asked Questions

Can I use NMN for my aging and age-related illnesses?
Ultra Pure NMN™ is not intended to diagnose, treat, cure, or prevent any disease, including age-related illnesses. While NMN has shown promise in scientific research for various age-related conditions and can complement mainstream Western medicine (see our Science Section), consulting your healthcare provider before incorporating NMN into your approach to managing any health condition is recommended.

How do I know if NMN will benefit me?
NMN's effects can vary from person to person. However, the majority of our customers report increased energy, improved cognitive function, and enhanced overall well-being after integrating NMN into their daily routines. You can explore our Science section to access available research related to the specific area of your interest.

How can I be sure that your NMN works?
Our Ultra Pure NMN™ products are supported by extensive research and are produced by the world's leading NMN manufacturer. We also subject them to third-party testing for purity and quality. Countless satisfied customers have experienced the benefits of our NMN, including increased energy and improved well-being.

Is NMN safe for me to use?
NMN is present in various foods such as broccoli, cucumber, avocado, and tomato, and it is also naturally produced in our bodies. It is generally considered safe for most individuals. However, if you have underlying health conditions or are taking medications, we recommend consulting your healthcare professional before starting any new supplement regimen.

How do I know if your NMN is pure and safe?
Quality is of paramount importance to us. In addition to sourcing from the top NMN manufacturer in the world, our Ultra Pure NMN™ undergoes rigorous testing for purity, heavy metals, and microbial content by reputable third-party labs registered with the U.S. FDA and accredited with ISO17025. This ensures that our NMN is of exceptional quality, with a purity level surpassing 99%. Our test results are readily accessible on our NMN product page, providing you with the assurance that our products are both safe and of the highest purity.

What if I'm not satisfied with your NMN?
Your satisfaction is our priority. If you're unsatisfied with our NMN products, we offer a risk-free return policy. Simply reach out to our customer support team within 60 days of receiving your products, and we'll be happy to assist you.

Can you guarantee your NMN is effective for me?
While we cannot ensure specific results for every individual, our Ultra Pure NMN™ is formulated based on scientific research and boasts exceptional purity. Our dedication to quality manufacturing and third-party testing guarantees that you're receiving a product with the potential to enhance your healthspan. Additionally, we offer a risk-free refund policy, allowing you to contact our customer service for a refund if you're not fully satisfied with the results.

Is your NMN capsule vegan-friendly?
Yes, our Ultra Pure NMN™ capsule is vegan-friendly. We are committed to providing an NMN product that does not contain any animal-derived ingredients.

Why don't you offer liposomal NMN?
While liposomal NMN could have validity, we have chosen to prioritize the original form of NMN, which has been the subject of extensive research. This form provides repeatable results consistent with the existing research. Our commitment as a research-driven company is to offer ultra-pure NMN with a purity exceeding 99%. This ensures optimal absorption and effectiveness for our customers, aligning with scientific evidence.

Why do you use sachet packaging instead of plastic bottles?
We are committed to environmental responsibility. Our eco-friendly sachet packaging reduces plastic waste by up to 90%, enhances recyclability, and promotes sustainability compared to plastic bottle packaging. This commitment reflects our dedication to both your well-being and the planet's health.

How long do I need to wait after placing my NMN order?
We promptly process orders, and you can expect to receive a confirmation email with tracking information within 1-2 business days. Shipping times may vary based on your location. After placing an order, you can anticipate U.S. domestic orders arriving within 3-7 business days and international orders within 5-12 business days. Delays may occur with international orders due to customs clearance.

Why is NMN expensive?
The manufacturing process of NMN involves several intricate steps and is cost-intensive. With advancements in the manufacturing process, NMN prices have significantly reduced in recent years. While NMN might seem pricey compared to other supplements, our dedication to quality and the potential benefits it offers make it a worthwhile investment in your healthspan and overall well-being.

Do you offer free shipping?
Yes, we offer free shipping for all orders over $50 within the US and international orders over $100. 

Convenient Bi-Monthly Subscription with Auto-Renewal

At HealthspanX, we offer a convenient bi-monthly subscription service with auto-renewal, ensuring that you never miss a day of optimal health. Our subscription plan ships two sachets every two months, making it easier for you to stay consistent with your supplement routine.

Flexible Return Policy
We understand that sometimes you may need to change your plans. That’s why our customers can cancel the subscription, send back unopened products for a refund at any time. Please see our Return and Refund Policy.

Why Choose HealthspanX Subscription?
Consistency: Receive two sachets every two months, ensuring uninterrupted supplement support.
Convenience: Set it and forget it with our auto-renewal feature.
Flexibility: Our global return process makes it easy to return unopened products if you're not completely satisfied.
Peace of Mind: Products are carefully inspected, allowing us to offer refunds without compromising quality.

Join the HealthspanX subscription service today and enjoy the ease and reliability of a plan designed to support your health journey every step of the way.

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Ultra Pure NMN™ 500mg Capsules

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and Razor-Sharp Focus

Here’s, In-Detail, How Ultra Pure NMN™ Transforms Your Life!

FeatureBenefitDetails
Ultra-High PurityMaximizes absorption and effectiveness.99%+ pharmaceutical-grade NMN ensures maximum bioavailability for optimal results.
Rigorous Third-Party TestingGuarantees safety and reliability.Every batch is tested for purity and potency to deliver consistent, high-quality results.
Vegan-Friendly FormulationSupports ethical and dietary choices.100% plant-based, allergen-free, and free of animal-derived ingredients.
Superior Manufacturing StandardsEnsures world-class product quality.Produced in ISO9001, HACCP, Kosher, and Halal certified facilities.
Exceptional Quality IngredientsProtects health with clean supplementation.Free from allergens, fillers, and artificial additives.
Affordable Health ElevationDelivers premium benefits at an accessible price.High-performance cellular health supplement without financial strain.
Free Shipping SpecialOffers seamless, cost-free delivery.Free U.S. shipping on orders over $50 and international orders over $100.
Risk-Free Purchase GuaranteeEliminates purchase risk.60-day “Feel 10 Years Younger” money-back guarantee—no questions asked.
Boosts NAD+ LevelsIncreases energy production and cellular health.Clinically shown to significantly raise NAD+ levels, fueling energy and longevity.
Enhances Muscle Strength & EnduranceImproves physical performance and recovery.Proven to boost stamina and accelerate post-exercise recovery.
Improves Insulin SensitivitySupports metabolic health and blood sugar control.Increases muscle glucose uptake, aiding in diabetes prevention.
Reduces Arterial StiffnessPromotes cardiovascular health.Decreases arterial stiffness, lowering the risk of heart disease.
Elevates Cognitive FunctionBoosts memory, focus, and mental clarity.Increases brain energy metabolism and reduces brain fog.
Improves Sleep QualityPromotes restful, rejuvenating sleep.Enhances sleep cycles, improving energy and recovery.
Reduces InflammationLowers joint pain and chronic disease risks.Activates anti-inflammatory pathways for better mobility and joint health.
Enhances Skin Health & ElasticityReduces wrinkles and improves skin texture.Supports collagen production and reduces oxidative stress for youthful skin.
Increases SIRTUIN ActivationSlows aging and supports DNA repair.Activates longevity genes, improving cellular repair and stress resistance.
Strengthens Immune FunctionBoosts the body’s defense against illness.Enhances immune responses by increasing NAD+ availability for immune cells.
Accelerates Post-Surgery RecoverySpeeds up healing and tissue repair.Promotes cellular repair mechanisms for faster recovery.
Supports Bone DensityReduces osteoporosis risk.Improves calcium absorption and bone strength, especially in aging populations.

Backed by Cutting-Edge Human Studies

See how Ultra Pure NMN™ delivers real, science-backed results

Enhanced Endurance

Energy Boost

High-Dose Safety

NAD+ Amplifier

Insulin Sensitivity

Heart Health

Metabolic Boost

Better Sleep & Strength

Muscle Performance

Anti-Aging Support

Nicotinamide Mononucleotide (NMN) Supplementation Enhances Aerobic Capacity
in Amateur Runners
Date: 2021
Published In: Journal of the International Society of Sports Nutrition

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a natural compound found in the body that helps make NAD+, a molecule that gives energy to cells and helps repair damage. As we age, our NAD+ levels drop, making it harder for our bodies to stay healthy and energized.
Previous research in animals showed that taking NMN along with exercise could boost endurance and muscle performance. However, no studies have been done on humans to confirm this.
This study tested whether NMN supplements could improve stamina and physical performance in people who already exercise regularly.

Study Design
Who Participated?
48 healthy runners (40 men and 8 women)
Ages: 27 to 50 years old
Exercise Background: 1–5 years of regular running or cycling

What Did They Do?
Duration: 6 weeks
Groups:
Control Group: Took a fake supplement (placebo)
Low NMN Dose: 300 mg/day
Medium NMN Dose: 600 mg/day
High NMN Dose: 1200 mg/day
Exercise Routine:
40–60 minutes of running or cycling, 5–6 days a week
Workout intensity was adjusted based on each person’s fitness level

How Did They Measure Progress?
Oxygen Use During Exercise (VO2): How well the body uses oxygen while working out
VO2max: The maximum amount of oxygen a person can use during intense exercise (higher VO2max = better fitness)
Power at Ventilatory Thresholds (VT1 & VT2): The highest workout intensity someone can maintain without running out of breath
Body Composition: Weight, body fat, and muscle mass
Safety: Heart checks (ECG) and side effect reports

Results
1. Oxygen Use and Exercise Performance:
VO2 at VT1 (First Breathlessness Point): Improved in those taking NMN, especially with higher doses.
Workout Power at VT1 and VT2 (Exercise Intensity): Stronger performance in the medium and high NMN groups.
VO2max (Overall Fitness): No big changes were seen across all groups.
2. Body Weight and Fat:
NMN did not affect weight, body fat, or muscle mass.
3. Safety:
NMN supplements were safe and caused no side effects. Heart tests during exercise were normal.

What This Means for You?
1- Better Endurance: NMN supplements can help you exercise longer and harder by making your muscles better at using oxygen.
2- Safe to Use: NMN caused no side effects, even at high doses.
3- Not a Weight-Loss Supplement: NMN won’t help you lose weight or change your body fat but can boost athletic performance.
4- Dose Matters: The higher the NMN dose, the bigger the improvement in stamina and exercise performance.

Nicotinamide Mononucleotide (NMN) Supplementation Enhances NAD+ Levels and Physical Performance in Middle-Aged Adults
Date: 2022
Published In: GeroScience

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a natural compound in the body that boosts levels of NAD+, a molecule essential for energy production and cellular repair. As we age, NAD+ levels drop, leading to fatigue and slower recovery.
Animal studies have shown NMN improves energy, endurance, and lifespan, but its effects in humans were not well-understood.
This study investigated whether NMN supplementation could increase energy levels, physical performance, and overall health in healthy middle-aged adults.

Study Design
Who Participated?
80 healthy men and women
Age Range: 40–65 years
Body Mass Index (BMI): 18.5–35 kg/m²
What Did They Do?
Duration: 60 days
Groups:
Placebo Group: Took a non-active supplement
Low Dose NMN: 300 mg/day
Medium Dose NMN: 600 mg/day
High Dose NMN: 900 mg/day

What Was Measured?
NAD+ Levels in Blood: Energy molecule vital for cellular health.
6-Minute Walking Test: Measured stamina and endurance.
Blood Biological Age: Assessed aging markers in the blood.
Quality of Life: Measured through the SF-36 Health Survey.
Safety and Tolerability: Checked for side effects.

Key Positive Results
1- Significant Increase in NAD+ Levels
NMN supplementation greatly increased NAD+ levels in all NMN groups by Day 30 and Day 60.
The 600 mg and 900 mg doses produced the highest NAD+ increases, supporting improved cellular energy.
2- Enhanced Physical Endurance
Participants in the 600 mg and 900 mg NMN groups walked farther during the 6-minute walking test.
Physical stamina improved significantly, with the 900 mg group achieving the longest walking distances.
3- Stabilized Biological Aging
In the placebo group, participants' biological age increased over 60 days.
In contrast, all NMN groups maintained their biological age, suggesting NMN may slow down age-related decline.
4- Improved Health and Well-being (SF-36 Scores)
Participants in the 600 mg and 900 mg NMN groups reported feeling healthier, more energetic, and mentally sharper.
Health survey scores were significantly higher than in the placebo group.
5- Excellent Safety and Tolerability
No serious side effects were reported in any NMN group, even at the highest 900 mg dose.
NMN was safe and well-tolerated throughout the study.

What This Means for You
1- Boosts Energy: NMN increases NAD+ levels, fueling energy production.
2- Better Endurance: NMN helps you exercise longer and harder by improving how muscles use oxygen.
3- Slows Aging: NMN may maintain a younger biological age.
4- Safe to Use: NMN is safe and well-tolerated, even in high doses.

Safety Evaluation of β-Nicotinamide Mononucleotide (NMN) Oral Administration in Healthy Adult Men and Women
Date: 2022
Published In: Scientific Reports

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound in the body that helps produce NAD+, a molecule essential for energy production, DNA repair, and healthy cell function. As we age, NAD+ levels decrease, contributing to fatigue and age-related diseases.
Animal studies have shown that NMN supplementation increases NAD+ levels and improves various health markers. However, limited research had been conducted to assess the safety of high-dose NMN supplementation in humans.
This study aimed to determine whether taking 1,250 mg of NMN daily is safe for healthy adults.

Study Design
Who Participated?
31 healthy men and women
Age Range: 20–65 years
Balanced groups: 15 in the placebo group, 16 in the NMN group

What Did They Do?
Duration: 4 weeks
Groups:
Placebo Group: Took an inactive supplement.
NMN Group: Took 1,250 mg/day of β-NMN.
Measurements Used to Track Safety:
Hematological Tests: Blood health markers.
Clinical Biochemical Tests: Organ function indicators.
Body Composition: Weight, BMI, fat percentage.
Urinalysis: Kidney function and hydration status.
Adverse Events: Tracking any side effects.

Key Positive Results
1- NMN Was Safe and Well-Tolerated
No serious side effects were reported during the 4-week period.
Minor issues (e.g., mild cold, loose stool) were unrelated to NMN.
2- No Negative Impact on Organ Function
Liver and kidney functions remained normal throughout the study.
Blood markers, such as enzymes and cholesterol levels, stayed within healthy ranges.
3- Stable Body Composition and Vital Signs
No significant changes in weight, BMI, fat percentage, or blood pressure.
4- No Abnormal Changes in Blood or Urine Tests
All blood and urine markers remained within normal clinical ranges.
No signs of toxicity or harmful metabolic effects.

What This Means for You
1- Safe at High Doses: Taking 1,250 mg/day of NMN is safe and well-tolerated for healthy adults.
2- No Negative Health Effects: NMN did not harm organ function or cause adverse effects.
3- Suitable for Long-Term Use: NMN can be considered a safe supplement for boosting energy and cellular health.

Oral Administration of Nicotinamide Mononucleotide (NMN) Is Safe and Efficiently Increases NAD+ Levels in Healthy Subjects
Date: 2022
Published In: Frontiers in Nutrition

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a natural molecule that helps produce NAD+, a critical compound that fuels energy production and supports DNA repair. NAD+ levels drop with age, leading to fatigue and slower recovery.
Animal studies have shown NMN can improve energy levels, endurance, and even delay aging. However, there was limited research on NMN's safety and its impact on NAD+ levels in humans.
This study aimed to determine if taking 250 mg of NMN daily for 12 weeks is safe and effective in increasing NAD+ levels in healthy adults.

Study Design
Who Participated?
30 healthy men and women
Age Range: 22–64 years

What Did They Do?
Duration: 12 weeks
Groups:
Placebo Group: Took an inactive supplement.
NMN Group: Took 250 mg/day of NMN (125 mg twice daily).

What Was Measured?
1- NAD+ Levels in Blood: Monitored the increase in cellular energy.
2 -Body Composition: Assessed muscle mass and body fat.
3- Clinical Blood Tests: Checked for organ function and metabolic health.
4- Adverse Events Monitoring: Tracked any side effects.

Key Positive Results
1- Significant Increase in NAD+ Levels
Participants taking NMN had a significant rise in blood NAD+ levels at 4, 8, and 12 weeks.
NAD+ levels returned to normal after stopping NMN, confirming the supplement's effect.
2- Safe and Well-Tolerated
No serious side effects were reported.
Only mild, temporary abdominal discomfort was noted in one participant, resolving on its own.
3- Potential Improvement in Body Composition
Although not statistically significant, NMN users showed a trend toward increased muscle mass and decreased body fat.
4- No Negative Impact on Organ Function
Liver and kidney function tests remained normal.
No changes in blood pressure, heart rate, or glucose levels were detected.

What This Means for You
1- Boosts Cellular Energy: NMN raises NAD+ levels, fueling energy production in cells.
2- Safe to Use: NMN is safe and well-tolerated, even with daily use for 12 weeks.
3- Supports Healthy Aging: By increasing NAD+, NMN may slow aging and improve metabolism.

Nicotinamide Mononucleotide (NMN) Increases Muscle Insulin Sensitivity in Prediabetic Women
Date: 2021
Published In: Science

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a compound that helps produce NAD+, a vital molecule for energy production and cellular repair. Aging and obesity are known to lower NAD+ levels, leading to reduced insulin sensitivity and impaired glucose metabolism.
Animal studies have shown that NMN supplementation can improve insulin sensitivity and metabolic health, but its impact on humans, particularly women with prediabetes, was not well studied.
This study aimed to determine if NMN supplementation improves muscle insulin sensitivity in overweight or obese postmenopausal women with prediabetes.

Study Design
Who Participated?
25 postmenopausal women with prediabetes
Age Range: Middle-aged to older adults
BMI Range: 25.3–39.1 kg/m² (overweight to obese)

What Did They Do?
Duration: 10 weeks
Groups:
Placebo Group: Took a non-active supplement.
NMN Group: Took 250 mg/day of NMN.

What Was Measured?
1- Muscle Insulin Sensitivity: Assessed using glucose disposal rates.
2- Insulin Signaling Pathways: Measured by protein activation in muscles (AKT and mTOR).
3- NAD+ Levels in Muscle and Blood: Checked for increases in NAD+ metabolism.
4- Gene Expression: Examined genes involved in muscle repair and glucose metabolism.
5- Safety: Monitored side effects and blood test results.

Key Positive Results
1- Improved Muscle Insulin Sensitivity
NMN supplementation increased insulin-stimulated glucose disposal by 25%, improving how muscles use glucose.
No improvement was seen in the placebo group.
2- Enhanced Insulin Signaling in Muscle
NMN boosted the activation of proteins AKT and mTOR, both critical for muscle glucose uptake and growth.
3- Increased Muscle NAD+ Metabolism
Although total NAD+ levels in muscle didn’t change, NAD+ turnover increased, suggesting enhanced energy metabolism.
4- Muscle Remodeling and Repair
NMN upregulated genes related to muscle repair and remodeling, particularly the PDGF signaling pathway, which is important for muscle growth and regeneration.
5- Safe and Well-Tolerated
No side effects or abnormal blood test results were reported in the NMN group.
Participants fully adhered to the supplement regimen.

What This Means for You
1- Better Blood Sugar Control: NMN improves how muscles use insulin, helping manage blood sugar.
2- Supports Muscle Health: NMN activates key proteins for muscle repair and glucose uptake.
3- Safe Supplement: NMN is safe and well-tolerated at 250 mg/day.
4- Potential Diabetes Prevention: NMN may help slow or prevent the progression of prediabetes.

Nicotinamide Adenine Dinucleotide Metabolism and Arterial Stiffness After Long-Term Nicotinamide Mononucleotide (NMN) Supplementation
Date: 2023
Published In: Scientific Reports

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a precursor to NAD+, a molecule essential for energy production, cellular repair, and healthy metabolic function. NAD+ levels naturally decline with age, contributing to various age-related conditions, including cardiovascular diseases (CVD).
Animal studies have demonstrated that NMN supplementation can restore NAD+ levels and improve vascular health. However, there was limited clinical evidence in humans, especially regarding its impact on arterial stiffness—a major risk factor for CVD.
This study aimed to assess whether 12 weeks of NMN supplementation could enhance NAD+ metabolism and reduce arterial stiffness in healthy middle-aged adults.

Study Design
Who Participated?
36 healthy middle-aged men and women
Age Range: 40–59 years

What Did They Do?
Duration: 12 weeks
Groups:
Placebo Group: Took a non-active supplement.
NMN Group: Took 250 mg/day of NMN (125 mg twice daily).

What Was Measured?
1- NAD+ Metabolism: Serum levels of NAD+, NMN, and nicotinamide (NAM).
2- Arterial Stiffness: Measured using brachial-ankle pulse wave velocity (baPWV).
3- Blood Pressure: Systolic and diastolic measurements.
4- Body Composition: Weight, BMI, and fat distribution.
5- Safety: Blood tests, urinalysis, and monitoring of adverse events.

Key Positive Results
1. Enhanced NAD+ Metabolism
Nicotinamide (NAM) levels in the blood increased by 57.6% in the NMN group, indicating enhanced NAD+ turnover.
This increase reflects improved NAD+ metabolism, supporting better cellular energy production.
2. Potential Reduction in Arterial Stiffness
Arterial stiffness (baPWV) decreased by 25.1 cm/s in the NMN group.
Participants with higher BMI or elevated blood glucose showed the greatest improvement in arterial health.
3. No Negative Impact on Blood Pressure or Metabolic Health
Blood pressure and metabolic markers (glucose, cholesterol) remained stable.
No significant weight gain or loss was observed.
4. Safe and Well-Tolerated
No serious side effects were reported throughout the study.
Blood and urine tests confirmed the safety of long-term NMN use.

What This Means for You
1- Supports Heart and Vascular Health: NMN may help reduce arterial stiffness, lowering the risk of heart disease.
2- Boosts Cellular Energy: NMN enhances NAD+ metabolism, supporting overall energy and metabolic health.
3- Safe for Long-Term Use: NMN at 250 mg/day is safe and well-tolerated.
4- Potential Benefits for Metabolic Health: Especially helpful for individuals with higher BMI or elevated blood sugar.

Effect of Oral Administration of Nicotinamide Mononucleotide (NMN) on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men
Date: 2019
Published In: Endocrine Journal

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a key molecule in the production of NAD+, a compound essential for energy production, DNA repair, and maintaining healthy cells. As people age, NAD+ levels naturally decline, contributing to fatigue, slower metabolism, and increased risk of age-related diseases.
Animal studies have shown NMN can improve NAD+ levels and prevent age-related diseases, but the safety and effectiveness of NMN in humans were not well understood.
This study aimed to evaluate the safety and metabolic effects of single-dose NMN supplementation in healthy Japanese men.

Study Design
Who Participated?
10 healthy Japanese men
Age Range: 40–60 years

What Did They Do?
Duration: Single-dose administration with follow-up for 5 hours
Groups:
Participants received 100 mg, 250 mg, or 500 mg of NMN in capsule form.
Administration: Oral intake after overnight fasting, with health monitoring for 5 hours.

What Was Measured?
1- Vital Signs: Heart rate, blood pressure, oxygen levels, and body temperature.
2- Blood and Urine Tests: Liver and kidney function, glucose levels, and blood chemistry.
3- Nicotinamide Metabolites: Blood levels of NMN metabolites like N-methyl-2-pyridone-5-carboxamide (2Py) and N-methyl-4-pyridone-5-carboxamide (4Py).
4- Ophthalmic Examination: Eye health and vision parameters.
5- Sleep Quality: Evaluated using the Pittsburgh Sleep Quality Index (PSQI)..

Key Positive Results
1. NMN Was Safe and Well-Tolerated
No serious side effects occurred at any dose, even with 500 mg of NMN.
No significant changes in heart rate, blood pressure, oxygen saturation, or body temperature.
2. Improved NAD+ Metabolism
NMN significantly increased plasma levels of key metabolites: 
2Py and 4Py levels increased dose-dependently, peaking at 300 minutes.
These results indicate that NMN was effectively absorbed and metabolized in the body.
3. Favorable Changes in Blood Markers
Mild, beneficial shifts in clinical markers were observed: 
Blood glucose levels decreased by 11.7%.
Creatinine and chloride levels slightly decreased.
Bilirubin levels increased by 51.3%, remaining within the normal range.
4. No Adverse Effects on Vision or Sleep
No significant changes in eye health or sleep quality across all doses.

What This Means for You
1- Safe Supplement: NMN up to 500 mg is safe and well-tolerated for healthy adults.
2- Boosts NAD+ Metabolism: NMN improves the body’s ability to process NAD+, potentially enhancing energy metabolism.
3- No Negative Health Effects: NMN does not harm organ function or overall health.
4- Potential for Age-Related Benefits: NMN could be used as a preventive strategy against age-related health decline.

Effect of 12-Week Intake of Nicotinamide Mononucleotide (NMN) on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults
Date: 2022
Published In: Nutrients

Background: Why This Study Was Done
As people age, they often experience poor sleep quality, increased fatigue, and declines in physical performance. These issues can significantly lower the quality of life and increase the risk of disease and mortality.
Nicotinamide Mononucleotide (NMN) is a natural compound that boosts NAD+ production, a molecule essential for energy production and cell repair. Previous research in animals suggests NMN can improve energy metabolism, muscle function, and delay aging.
This study explored whether 12 weeks of NMN supplementation could improve sleep quality, reduce fatigue, and enhance physical performance in older Japanese adults.

Study Design
Who Participated?
108 healthy Japanese men and women
Age: 65 years and older
Divided into four groups:
NMN Morning (NMN_AM): 250 mg NMN taken in the morning
NMN Evening (NMN_PM): 250 mg NMN taken in the evening
Placebo Morning (Placebo_AM): Placebo taken in the morning
Placebo Evening (Placebo_PM): Placebo taken in the evening

What Did They Do?
Duration: 12 weeks
Dose: 250 mg/day of NMN or placebo
Measurements: Taken at the start, midpoint (6 weeks), and end (12 weeks).

What Was Measured?
1- Sleep Quality: Assessed by the Pittsburgh Sleep Quality Index (PSQI).
2- Fatigue Levels: Measured using the Jikaku-sho shirabe questionnaire.
Physical Performance: 3- Tested through:
    Grip strength
    5-times sit-to-stand (5-STS)
    Timed Up and Go (TUG)
    (5) meter habitual walk
4- Safety: Tracked adverse events and monitored health markers.

Key Positive Results
1. Improved Physical Performance
The NMN_PM (evening) group had significant improvement in lower limb strength measured by the 5-STS test.
The effect size was largest in the NMN_PM group (d = 0.72), indicating a strong improvement in muscle function.
2. Reduced Drowsiness and Fatigue
Drowsiness significantly improved in the NMN_PM group compared to other groups.
Participants reported feeling less tired and more alert, with a medium effect size of d = 0.64 for drowsiness reduction.
3. Enhanced Sleep Quality
The NMN_PM group experienced improvements in sleep latency (time taken to fall asleep), daytime dysfunction, and overall sleep quality.
Sleep quality effect size: d = 0.80, suggesting a strong positive effect.
4. Safe and Well-Tolerated
No serious side effects were reported during the 12-week period.
NMN was well-tolerated, with a high supplement adherence rate (>95%).

What This Means for You
1- Better Sleep: Taking NMN in the evening can improve sleep quality and help you fall asleep faster.
2- More Energy and Less Fatigue: NMN reduces drowsiness and fatigue, helping you feel more alert.
3- Improved Strength: NMN boosts lower body strength, enhancing mobility and reducing the risk of falls.
4- Safe for Older Adults: NMN is safe and well-tolerated for long-term use.

Chronic Nicotinamide Mononucleotide (NMN) Supplementation Elevates Blood NAD+ Levels and Improves Muscle Function in Healthy Older Men
Date: 2022
Published In: NPJ Aging

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a precursor to NAD+, a molecule critical for energy production, DNA repair, and overall cellular health. NAD+ levels naturally decline with age, contributing to muscle weakness, fatigue, and age-related diseases.
Animal studies have shown that NMN supplementation restores NAD+ levels and improves muscle health, but more evidence in older humans was needed.
This study aimed to evaluate whether 250 mg/day of NMN for 12 weeks could safely boost NAD+ levels and improve muscle strength and performance in healthy older men.

Study Design
Who Participated?
42 healthy Japanese men
Age: 65 years and older
Divided into two groups:
Placebo Group: Took a non-active supplement.
NMN Group: Took 250 mg/day of NMN.

What Did They Do?
Duration: 12 weeks
Dose: 250 mg/day of NMN or placebo
Assessments: Conducted at baseline, week 6, and week 12

What Was Measured?
1- NAD+ Levels in Blood: Measured to evaluate energy metabolism.
2- Muscle Strength and Performance: Assessed through:
Gait speed (walking speed)
Grip strength (hand strength)
30-second chair-stand test (lower body strength)
3- Body Composition: Measured muscle mass and fat distribution.
4- Safety: Monitored blood markers and adverse events.

Key Positive Results
1. Significant Increase in NAD+ Levels
NMN supplementation significantly increased NAD+ and NAD+-related metabolites in blood after 12 weeks.
NAD+ metabolism was effectively stimulated, supporting better cellular energy production.
2. Improved Muscle Performance
Gait speed significantly improved in the NMN group by Week 12.
Left-hand grip strength also improved, indicating better muscle function.
Participants performed better in the 30-second chair-stand test, reflecting enhanced lower-body strength.
3. Safe and Well-Tolerated
No serious side effects were reported throughout the 12-week period.
Blood and urine tests showed normal organ function.
4. No Impact on Body Composition
Muscle mass and fat distribution remained unchanged, suggesting that NMN primarily improved muscle performance without altering body weight.

What This Means for You
1- Boosts Cellular Energy: NMN significantly raises NAD+ levels, improving energy metabolism.
2- Stronger Muscles: NMN improves muscle strength and mobility, helping prevent age-related muscle decline.
3- Safe for Older Adults: NMN at 250 mg/day is safe and well-tolerated for long-term use.
4- Supports Healthy Aging: NMN may help maintain muscle function and mobility in older adults.

Efficacy and Safety of Nicotinamide Mononucleotide (NMN) Supplementation in Middle-Aged and Older Adults
Date: 2022
Published In: Frontiers in Aging

Background: Why This Study Was Done
Nicotinamide Mononucleotide (NMN) is a vital compound that boosts levels of NAD+, a molecule essential for cellular energy production, DNA repair, and overall health. As we age, NAD+ levels decline, contributing to fatigue, metabolic slowdowns, and various age-related diseases.
This study aimed to evaluate the anti-aging effects and safety of NMN supplementation in middle-aged and older adults by examining its impact on NAD+ levels, physical performance, and metabolic health.

Study Design
Who Participated?
62 healthy adults (31 in the NMN group, 31 in the placebo group)
Age Range: 40–65 years
BMI Range: 18.5–35 kg/m²

What Did They Do?
Duration: 60 days
Groups:
NMN Group: Took 300 mg/day of NMN (two 150 mg doses).
Placebo Group: Took identical placebo capsules.

What Was Measured?
1- NAD+/NADH Levels: Blood markers of cellular energy.
2- Physical Performance: Assessed using the 6-minute walking test.
3- Quality of Life: Measured with the SF-36 Health Survey.
4- Insulin Sensitivity: Monitored through the HOMA-IR index, fasting glucose, and insulin levels.
5- Safety: Evaluated through lab tests and side effect monitoring.

Key Positive Results
1. Significant Increase in NAD+/NADH Levels
After 30 days, NAD+/NADH levels rose by 11.3% in the NMN group.
By day 60, NAD+/NADH levels increased by 38%, while the placebo group only saw a 14.3% rise.
2. Improved Physical Endurance
Participants in the NMN group increased their 6-minute walking distance by 6.5% after 60 days, compared to a 3.9% increase in the placebo group.
3. Enhanced Quality of Life (SF-36 Scores)
SF-36 health survey scores improved by 6.5% in the NMN group, nearly twice the 3.4% improvement in the placebo group.
Participants reported feeling more energetic, happier, and physically healthier.
4. Stabilized Insulin Sensitivity (HOMA-IR Index)
The HOMA-IR index rose by only 0.6% in the NMN group, showing stable insulin sensitivity.
In contrast, the placebo group saw a 30.6% increase in insulin resistance.
Fasting blood sugar levels dropped by 4% in the NMN group but rose by 6.5% in the placebo group.
5. Safe and Well-Tolerated
No serious side effects were reported.
Only one mild case of dyslipidemia occurred in each group, which resolved on its own.
No negative effects on organ function or blood markers were observed.

What This Means for You
1- Boosts Energy Levels: NMN significantly increases NAD+ levels, enhancing cellular energy.
2- Better Physical Endurance: NMN improves stamina and mobility over time.
3- Improves Quality of Life: NMN supports both physical and mental well-being.
4- Supports Metabolic Health: NMN helps maintain stable insulin sensitivity, reducing diabetes risk.
5- Safe for Daily Use: NMN is safe and well-tolerated for long-term use.

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